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@Liz10Ohio you can use it twice a day but i use it every other day because it can dry out your skin and i live in a low humidity area...but yes you can use it day and night.
@LilyCHicago you use Benzoyl Peroxide 10 as a spot treatment or if you have acne all over just use a little bit all over after you wash your face..it is not a lotion so you will want to use a lotion after with spf 15 or higher.